Comparison of osteoprotegerin and vascular endothelial growth factor in normoalbuminuric Type 1 diabetic and control subjects
Comparison of osteoprotegerin and vascular endothelial growth factor in normoalbuminuric Type 1 diabetic and control subjects
Alireza Esteghamati, M.D. 1,*, Alireza Arefzadeh, M.D. 1, Ali Zandieh, M.D., M.P.H. 1,
Mohammad Salehi Sadaghiani, M.D., M.P.H. 1, Sina Noshad, M.D., M.P.H. 1, Manouchehr
Nakhjavani, M.D. 1
1 Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of
Medicine, Tehran University of Medical Sciences, Tehran, Iran.
* Address correspondence to Alireza Esteghamati, Endocrinology and Metabolism
Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical
Sciences, Tehran, Iran.
Abstract:
Background: The aim of the current study was to evaluate the association of osteoprotegerin
and vascular endothelial growth factor (VEGF) with glycaemic indices and diabetes status.
Methods: A total of 44 normoalbuminuric type-1 diabetic patients and 44 healthy control
subjects, matched for age, body mass index, sex ratio and lipid measures were enrolled.
Univariate and multivariate logistic regression analyses were used to determine the association of
osteoprotegerin and VEGF with diabetes status. Further, linear regression analysis was
performed to investigate the roles of osteoprotegerin and VEGF as determinants of hemoglobin
A1c (HbA1c).
Results: Osteoprotegerin and VEGF were significantly elevated in diabetic subjects
(2.76±0.85 vs. 2.26±0.75 pmol/l and 187.1±92.7 vs. 125.9±52.3 pg/ml, respectively, P <0.01)
and were positively correlated with glycaemic indices (i.e. fasting plasma glucose and HbA1c, P
<0.001). After controlling for possible confounding factors odds ratios (confidence interval) of
osteoprotegerin and VEGF for diabetes were 2.113 (1.043-4.280) and 1.014 (1.002-1.026),
respectively (P <0.05). Further, linear regression analysis revealed that the association of
osteoprotegerin with HbA1c is independent of VEGF and vice versa (P <0.001).
Conclusion: Osteoprotegerin and VEGF are elevated in normoalbuminuric type 1 diabetic
subjects and are independently associated with glycaemic indices and diabetes status.